| Day | Date | Opponent | Location | Outcome/Time |
| Sun | 11/05/2000 | Houston Jaguars (Exh) | Nacogdoches, Texas | W, 80-73
Recap | Stats | Live Audio |
| Thu | 11/09/2000 | Spartak-Moscow (Exh) | Nacogdoches, Texas | W, 67-60
Stats | Live Audio |
| Fri | 11/17/2000 | Alcorn State # | Nacogdoches, Texas
(CONOCO Classic) | W, 88-46
Stats | Live Audio |
| Sat | 11/18/2000 | Consolation/Championship | Nacogdoches, Texas
(CONOCO Classic) | W, 69-62
Stats | Live Audio |
| Fri | 11/24/2000 | Arizona State | Honolulu | L, 67-45
Stats | Live Audio |
| Sat | 11/25/2000 | UC-Irvine | Honolulu | W, 65-44
Stats | Live Audio |
| Sun | 11/26/2000 | Michigan | Honolulu | L, 74-49
Stats | Live Audio |
| Sat | 12/02/2000 | Maine | Nacogdoches, Texas | W, 74-71 (2OT)
Stats | Live Audio |
| Thu | 12/07/2000 | Southwest Texas* | San Marcos, Texas | W, 57-48
Recap | Live Audio |
| Sat | 12/09/2000 | Texas-San Antonio* | San Antonio | W, 67-53
Recap | Live Audio |
| Sun | 12/17/2000 | Texas-Christian Univ. | Fort Worth, Texas | L, 67-56
Recap | Stats | Live Audio |
| Wed | 12/20/2000 | Prairie View A&M | Nacogdoches, Texas | W, 67-52
Recap | Stats | Live Audio |
| Thu | 12/28/2000 | Nicholls State* | Nacogdoches, Texas | W, 69-34
Recap | Stats | Live Audio |
| Sat | 12/30/2000 | Southeastern Louisiana* | Nacogdoches, Texas | W, 69-47
Recap | Stats | Live Audio |
| Thu | 01/04/2001 | Lamar* | Beaumont, Texas | W, 66-36
Recap | Stats | Live Audio |
| Sat | 01/06/2001 | Sam Houston* | Nacogdoches, Texas | W, 79-51
Recap | Stats | Live Audio |
| Thu | 01/11/2001 | Louisiana-Monroe* | Nacogdoches, Texas | W, 86-67
Recap | Stats | Live Audio |
| Sat | 01/13/2001 | Northwestern State* | Nacogdoches, Texas | W, 80-63
Recap | Stats | Live Audio |
| Sat | 01/20/2001 | McNeese State* | Lake Charles, La. | W, 93-47
Recap | Stats | Live Audio |
| Mon | 01/22/2001 | Texas-Arlington* | Nacogdoches, Texas | W, 72-49
Recap | Stats | Live Audio |
| Thu | 01/25/2001 | Sam Houston* | Huntsville, Texas | W, 77-51
Recap | Stats | Live Audio |
| Sat | 01/27/2001 | Lamar* | Nacogdoches, Texas | W, 68-55
Recap | Stats | Live Audio |
| Thu | 02/01/2001 | Southeastern Louisiana* | Hammond, La. | W, 65-49
Recap | Stats | Live Audio |
| Sat | 02/03/2001 | Nicholls State* | Thibodaux, La. | W, 71-58
Recap | Stats | Live Audio |
| Thu | 02/08/2001 | Texas-San Antonio* | Nacogdoches, Texas | W, 58-49
Recap | Stats | Live Audio |
| Sat | 02/10/2001 | Southwest Texas* | Nacogdoches, Texas | W, 86-54
Recap | Stats | Live Audio |
| Thu | 02/15/2001 | McNeese State* | Nacogdoches, Texas | W, 82-73
Recap | Stats | Live Audio |
| Sun | 02/18/2001 | UC Santa Barbara | Nacogdoches, Texas | L, 62-57
Recap | Stats | Live Audio |
| Sat | 02/24/2001 | Texas-Arlington* | Arlington, Texas | W, 62-52
Recap | Stats | Live Audio |
| Thu | 03/01/2001 | Northwestern State* | Natchitoches, La. | L, 58-55
Recap | Stats |
| Sat | 03/03/2001 | Louisiana-Monroe* | Monroe, La. | L, 56-51
Recap | Stats | Live Audio |
| Tue | 03/06/2001 | Southwest Texas | Nacogdoches, Texas
(SLC Tournament) | W, 79-42
Recap | Stats | Live Audio |
| Thu | 03/08/2001 | Texas-San Antonio | Bossier City, La.
(SLC Tournament) | W, 49-32
Stats | Live Audio |
| Sat | 03/10/2001 | Northwestern St. | Bossier City, La.
(SLC Tournament) | W, 82-73
Recap | Stats | Live Audio |
| Sat | 03/17/2001 | Rutgers | Piscataway, N.J.
(NCAA Tournament) | L, 80-43
Recap | Stats | Live Audio |
